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| TAG’s Michael Palm Basic Science, Vaccines & Prevention Project works to strengthen basic science, immunology, and biomedical HIV prevention research efforts directed at clarifying understanding of how HIV destroys the immune system, how to develop effective immune-based therapy strategies, and how to develop biomedical preventive approaches such as vaccines, microbicides, and treatments to prevent HIV infection pre- and post-exposure. For more information, see “Michael Palm Project Grant Awarded.” |  |
Michael Palm Basic Science, Vaccines & Prevention Project Weblog
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The Michael Palm Basic Science, Vaccine & Prevention Project is conducting an ongoing series of interviews with scientists whose work focuses on issues relating to the immunology, pathogenesis and biomedical prevention of HIV infection.
- Interview with Steven Deeks of UCSF (posted 11/30/2007)
- Discussing the pathogenesis of drug resistance, focusing on virus host interactions and how reductions in viral fitness can lead to improved immunologic outcomes.
- Interview with Douglas Nixon
- Discussing the pathogenesis of drug resistance, focusing on virus host interactions and how reductions in viral fitness can lead to improved immunologic outcomes.
Current Project Articles
- TAG Position Statement on the Proposed PAVE100A Vaccine Trial
Also available in Spanish on the website of Grupo de Trabajo sobre Tratamientos del VIH - TAG's Response to NIAID "Request for Information" on Priorities in Basic HIV Vaccine Research (added 5/28/08)
- Post-Merck Vaccine Pipelines
Information on the current preventive HIV vaccine pipeline, annotated with commentary and links to published and presented data. (added 5/27/08) - Merck Vaccine Fails
Immunizations in a trial of Merck’s HIV vaccine were stopped when it was determined that the vaccine was not working. There are now concerns that the vaccine may have increased the risk of HIV infection in some participants. - Immune Activation in HIV Infection: More than Just Markers
TAG calls for expanding investigations on immune activation in HIV pathogenesis. - TAG Updates on the Merck HIV Vaccine Trial (STEP/HVTN 502)
Information, links and commentary regarding the results of the Merck HIV vaccine trial presented on November 7 in Seattle. - Notes from the NIAID Workshop on Immune Activation and HIV Pathogenesis
- The PD-1 Palaver
Does a new molecule labeled "program death-1" (PD-1) play a role in shutting down virus-specific T cell responses? - Gut Reactions
a renewed interest in studying the potential impact of HIV infection on CD4 T cells in the gut in the hopes of answering outstanding questions about HIV pathogenesis. - Immune Based Therapies & Preventive Technologies Pipeline Tables
Preventive Vaccines • Microbicides • Pre-Exposure Prophylaxis (PrEP) • Therapeutic Vaccines • Cytokine & Immunomodulators • Gene Therapies - SMART Stops Stopping
Article on the termination of the Strategies for the Management of AntiRetoviral Therapy treatment interruption trial. - Co-Receptor Conundrum
The complex biology of chemokine receptors, a new target for HIV therapeutics. - Research on Pre-Exposure Prophylaxis (PrEP)
On April 25, 2006 TAG co-sponsored a community forum about Research on Pre-Exposure Prophylaxis (PrEP) with CHAMP and GMHC. Background information and Powerpoint presentations are available on CHAMP’s website. - That was the Year That Was: 2005 Year in Review
News updates from TAG's Michael Palm Basic Science, Prevention, and Vaccines Project are published on an ongoing basis on the Project weblog (added 02/07/2006) - Treatment Action Group Statement on the Termination of the SMART Study
- Cure Story Circulates
Story from "News of the World," a UK tabloid, added to Basic Science blog. Review and commentary. - TAG's Basic Science & Vaccine Project Weblog
Introducing TAG's Basic Science Project blog with highlighted articles and abstracts from September's science journal publications. Comments are welcome. - Immune-Based Therapies and Preventive Technologies Pipeline
Chapter in pdf format
for downloading • full report also available.
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